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Abstract #0789

Fast 3D cardiac extracellular volume mapping and cine imaging via continuous free-breathing acquisition with mid-scan contrast agent injection

Wonil Lee1, Paul Kyu Han1, Thibault Marin1, Ismaël B.G. Mounime1,2, Felicitas J. Bijari1, Marc D. Normandin1, Georges El Fakhri1, and Chao Ma1
1Yale School of Medicine, New Haven, CT, United States, 2LTCI, Télécom Paris, Institut Polytechnique de Paris, Paris, France

Synopsis

Keywords: Myocardium, Cardiovascular, Extracellular volume fraction (ECV)

Motivation: Three-dimensional cardiac extracellular volume (ECV) mapping and cine imaging are challenging due to respiratory and cardiac motions. Existing ECV mapping methods wait at least 10-minutes after contrast agent administration which increases the total scan time.

Goal(s): To develop a time-efficient method for free-breathing 3D cardiac ECV mapping and cine imaging.

Approach: Data was acquired continuously using inversion recovery spoiled gradient-echo (IR-SPGR) with mid-scan contrast agent administration. The Linear Tangent Space Alignment (LTSA) model was used for image reconstruction.

Results: Three-dimensional cardiac ECV maps and cine images were obtained in a 20-minute free-breathing scan with contrast agent injection in between.

Impact: We propose a highly time-efficient, free-breathing 3D cardiac imaging method that integrates ECV mapping and cine imaging in a single scan with mid-scan contrast agent injection.

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Keywords