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Abstract #0793

Fat-Water MR Elastography with Distributed Encoding for Accelerated Imaging of Brain and Skull Displacement

Alexa Diano1, Alex M Cerjanic1,2, Olivia M Bailey1, Mary K Kramer1, Joy Mojumder3, Dzung L Pham3, and Curtis L Johnson1
1Biomedical Engineering, University of Delaware, Newark, DE, United States, 2Neurology, Massachusetts General Hospital, Boston, MA, United States, 3Radiology and Radiological Sciences, Uniformed Services University of the Health Sciences, Bethesda, MD, United States

Synopsis

Keywords: Elastography, Elastography

Motivation: There exists a need for a noninvasive method capable of capturing skull-brain dynamics in vivo to provide accurate input parameters for computational models of traumatic brain injury.

Goal(s): We aimed to develop an accelerated fat-water imaging technique to quantify relative skull-brain displacement using magnetic resonance elastography (MRE).

Approach: Elastography with distributed generalized encoding was used to accelerate our previously developed fat-water MRE sequence to enable more extensive data collection in a single imaging session.

Results: This technique was able to simultaneously image skull and brain displacement with sufficient harmonic wave displacement to capture brain mechanical properties and bulk motion comparable to previous studies.

Impact: Quantifying relative skull-brain motion with the proposed sequence will help researchers define the transfer of skull-to-brain force transmission for ultimately determining regional variation in tissue displacement throughout the brain and the influence of different directions and frequencies of applied motion.

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