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Abstract #0796

Mechanically anisotropic phantoms for magnetic resonance elastography

Kevin N Eckstein1, Daniel Yoon1, Margrethe Ruding1, Ramin Balouchzadeh1, Aaliyah Thompson-Mazzeo1, Ruth J Okamoto1, Curtis L Johnson2, Matthew DJ McGarry3, and Philip V. Bayly1,4
1Mechanical Engineering and Materials Science, Washington University in St. Louis, Saint Louis, MO, United States, 2Biomedical Engineering, University of Delaware, Newark, DE, United States, 3Thayer School of Engineering, Dartmouth College, Hanover, NH, United States, 4Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO, United States

Synopsis

Keywords: Elastography, Elastography

Motivation: Imaging phantoms with known anisotropic mechanical properties are needed to evaluate magnetic resonance elastography (MRE) methods to estimate anisotropic parameters.

Goal(s): Fabricate mechanically anisotropic phantoms, characterize their mechanical behavior by direct testing, then assess the accuracy of MRE estimates of anisotropic properties.

Approach: Directionally scaled and unscaled lattices were designed to exhibit anisotropic or isotropic mechanical properties when embedded in a gelatin phantom. From MRE data, a transversely isotropic nonlinear inversion (TI-NLI) algorithm estimated maps of stiffness and mechanical anisotropy.

Results: MRE of scaled lattice-composites revealed elliptical wavefields; TI-NLI analysis estimated anisotropic properties that agreed with benchtop testing results.

Impact: The accurate detection of mechanical anisotropy within our phantom builds the credibility of anisotropic MRE techniques, which could have future clinical use to detect pathological changes to fibrous tissues like brain white matter.

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