Abstract #0801

Prospective Validation of Hybrid Multidimensional MRI for Prostate Cancer Detection using Targeted Biopsy: Comparison with PIRADS

Aritrick Chatterjee^1,2, Ambereen Yousuf¹, Roger Engelmann¹, Carla Harmath¹, Luke Reynold³, Tatjana Antic⁴, Mihai Guircanu⁵, Gregory S Karczmar^1,2, and Aytekin Oto^1,2

¹Department of Radiology, University of Chicago, Chicago, IL, United States, ²Sanford J. Grossman Center of Excellence in Prostate Imaging and Image Guided Therapy, University of Chicago, Chicago, IL, United States, ³Department of Urology, University of Chicago, Chicago, IL, United States, ⁴Department of Pathology, University of Chicago, Chicago, IL, United States, ⁵BSD Public Health Sciences, University of Chicago, Chicago, IL, United States

Synopsis

Keywords: Prostate, Prostate

Motivation: Quantitative tools may improve PCa diagnosis

Goal(s): The purpose of this study is to evaluate the effectiveness of an automated HM-MRI-based tool to prospectively identify targets before MR-US fusion biopsy in comparison with PIRADS based evaluation by expert radiologists.

Approach: Patients underwent 3T mpMRI along with HM-MRI. Patients received 12-core TRUS-guided sextant random biopsy. Additional biopsy targets selected by radiologist (≥PI-RADS 3) and suspected PCa based on HM-MRI were biopsied, using a Uronav MR-US fusion biopsy device.

Results: The diagnostic performance of HM-MRI for diagnosing clinically significant cancers (≥Gleason 3+4), was either higher than, or on par with that of mpMRI.

Impact: HM-MRI provides automated, quantitative image interpretation, standardized image acquisition, and reproducible results that improves MR-US fusion biopsy by providing more reliable detection of csPCa compared to PIRADS based evaluation by expert radiologists and potentially reduce the number of unnecessary biopsies.

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