Abstract #0802

Changes in Sodium MRI, Diffusion-Weighted MRI, and PSMA-PET 3-Months Post-Androgen Deprivation Therapy in Patients with Prostate Cancer

Josephine Lydia Tan¹, Alireza Akbari^2,3, Vibhuti Kalia^4,5, Timothy J Scholl^1,2,6, Jonathan D Thiessen^1,3,4,7,8, and Glenn Bauman^1,9

¹Medical Biophysics, Western University, London, ON, Canada, ²Robarts Research Institute, London, ON, Canada, ³Lawson Imaging, Lawson Health Research Institute, London, ON, Canada, ⁴Medical Imaging, Western University, London, ON, Canada, ⁵Medical Imaging, St. Joseph's Health Care, London, ON, Canada, ⁶Ontario Institute for Caner Research, Toronto, ON, Canada, ⁷Medical Physics, CancerCare Manitoba, Winnipeg, MB, Canada, ⁸Radiology, University of Manitoba, Winnipeg, MB, Canada, ⁹Oncology, Western University, London, ON, Canada

Synopsis

Keywords: Prostate, Cancer, tissue sodium concentration; apparent diffusion coefficient; standardized uptake value; androgen deprivation therapy

Motivation: Androgen deprivation therapy (ADT) is used to treat intermediate- to high-risk prostate cancer (PCa) and significantly alters prostate anatomy. However, there are limited imaging studies investigating treatment response on a functional and molecular level.

Goal(s): To assess tissue sodium concentration (TSC) measured by sodium MRI as a biomarker for ADT response in PCa.

Approach: TSC was quantified in 14 participants with PCa using sodium MRI before and after 3 months of ADT. Diffusion-weighted MRI and prostate-specific membrane antigen positron emission tomography (PSMA-PET) were also performed as clinical references.

Results: Increased tumour TSC and decreased PSMA tracer uptake were observed post-ADT.

Impact: For the first time, sodium MRI was used to measure changes in tissue sodium concentration pre- and post-androgen deprivation therapy in patients with prostate cancer. These findings may provide further insight on tumour response to ADT at a molecular level.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.