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Abstract #0809

Hyperpolarized [1-13C]pyruvate to [1-13C]lactate Conversion Rate with mpMRI to Distinguish Pathologically Aggressive Prostate Cancer

Matthew Gibbons1, Hsin-Yu Chen1, Peder EZ Larson1, Jeremy Gordon1, James Slater1, Rahul Aggarwal2, Matthew Cooperberg3, Peter Carroll3, Romelyn Delos Santos1, Jeffry P Simko4, Rosalie Nolley1, Donna M Peehl1, Renuka Sriram1, Susan M Noworolski1, Daniel B Vigneron1, John Kurhanewicz1,3, and Robert Bok1
1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, United States, 3Urology, University of California, San Francisco, San Francisco, CA, United States, 4Pathology, University of California, San Francisco, San Francisco, CA, United States

Synopsis

Keywords: Hyperpolarized MR (Non-Gas), Prostate, quantitative imaging

Motivation: There is a pressing clinical need to distinguish aggressive from indolent prostate cancer (PCa).

Goal(s): This study’s objective was to quantify the capability of Hyperpolarized (HP) [1-13C]pyruvate magnetic resonance imaging (MRI) to distinguish aggressive from indolent PCa.

Approach: A prospectively enrolled patient cohort underwent 3T multiparametric 1H/HP13C MRI followed by prostatectomy and whole-mount histopathology. Multivariate logistic regression was performed to classify lesions.

Results: Statistically significant differences for imaging parameters were observed between low-grade and high-grade PCa. The multivariate model including kPL, ADC, and DCE enhancement slope (ES) predicted aggressive disease with a ROC area under curve = 0.93.

Impact: There is a pressing clinical need to distinguish aggressive from indolent prostate cancer (PCa). Hyperpolarized [1-13C]pyruvate magnetic resonance imaging in combination with 1H multiparametric MRI has demonstrated potential to identify aggressive disease with high accuracy.

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Abstract Presentation Video

Keywords