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Abstract #0813

Towards Single-Shot Whole-Heart T1 Mapping Within Four Seconds

Daniel Mackner1, Moritz Blumenthal1, Nick Scholand1,2, Markus Huemer1, Martin Schilling3, Vitali Telezki3, Xiaoqing Wang4, and Martin Uecker1,2,3,5
1Institute of Biomedical Imaging, Graz University of Technology, Graz, Austria, 2DZHK (German Centre for Cardiovascular Research), Partner Site Göttingen, Göttingen, Germany, 3Institute for Diagnostic and Interventional Radiology, University Medical Center Göttingen, Göttingen, Germany, 4Department of Radiology, Harvard Medical School, Boston, MA, United States, 5BioTechMed-Graz, Graz, Austria

Synopsis

Keywords: Quantitative Imaging, Quantitative Imaging, T1 mapping, Myocardial T1, Subspace Reconstruction

Motivation: While$$$~T_1~$$$of the whole heart provides valuable diagnostic information, conventional methods are limited to single-slice acquisitions requiring multiple acquisitions and prolonging measurements due to repetitive breath-holds.

Goal(s): Development of rapid multi-slice $$$T_1~$$$mapping with high spatial resolution.

Approach: A radial single-shot IR-FLASH with slice-interleaved SMS-readout and total acquisition time of four seconds is combined with model-based reconstruction exploiting a linear subspace.
The technique was validated in phantom and in-vivo scans.

Results: Accuracy of $$$T_1$$$ in a phantom study were independent of simulated heart-rates with mean difference under$$$~8~ms$$$. Nine high-resolution short-axis myocardial$$$~T_1~$$$maps with whole-heart coverage were compared to Open-MOLLI and single-slice IR-FLASH showing a difference of$$$~38~ms$$$.

Impact: High resolution multi-slice $$$T_1$$$ quantification covering the whole-heart can be achieved within a short breath-hold of four seconds, which improves patient comfort, reduces motion artifacts, and improves the clinical feasibility of whole-heart $$$T_1$$$ mapping.

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Keywords