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Abstract #0814

Diffusion Tensor Imaging of Short T2 Tissues Using Quantitative Ultrashort Echo Time Double Echo Steady State (qUTE-DESS)

Jinil Park1, Sam Sedaghat2, Eddie Fu1, Youngkyoo Jung1, Lorenzo Nardo1, Abhijit Chaudhari1, Heejung Bang3, and Hyungseok Jang1
1Department of Radiology, University of California, Davis, Sacramento, CA, United States, 2Department of Radiology, University Hospital Heidelberg, Heidelberg, Germany, 3Department of Public Health Sciences, University of California, Davis, Sacramento, CA, United States

Synopsis

Keywords: Quantitative Imaging, MSK

Motivation: There is currently no effective diffusion tensor imaging (DTI) technique for short T2 tissues.

Goal(s): This study aims to demonstrate the feasibility of quantitative UTE-DESS (qUTE-DESS) for DTI of both short and long T2 tissues in the musculoskeletal system.

Approach: qUTE-DESS was implemented on a 3T clinical scanner and validated using agarose and sucrose phantoms, a celery phantom, a porcine specimen, and a knee joint from a healthy volunteer.

Results: qUTE-DESS produced high-resolution DTI parameter maps, including fractional anisotropy (FA) and mean diffusivity (MD), effectively detecting short T2 tissues such as tendon, ligament, and meniscus, as well as long T2 tissues.

Impact: qUTE-DESS-based DTI may provide accurate information on collagen (via FA) and proteoglycan content (via MD) in both short and long T2 tissues throughout the joint, enabling a comprehensive assessment of musculoskeletal disorders such as osteoarthritis.

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