Abstract #0821

Quantitative comparison of multi-echo spin echo and multi-echo gradient echo myelin water imaging in a panel of Mbp-enhancer edited mouse strains

Vladimir Grouza^1,2, Yawen Shi¹, Sean Goldfarb^2,3, Klaudia Monika Bednarz^2,3, Marius Tuznik¹, Hooman Bagheri⁴, Alan Peterson^2,4,5, Thomas Stroh^2,3,6, and David A Rudko^1,2,7

¹McConnell Brain Imaing Centre, Montreal Neurological Institute and Hospital, Montreal, QC, Canada, ²Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada, ³Neuro Microscopy Core Facility, Montreal Neurological Institute and Hospital, Montreal, QC, Canada, ⁴Department of Human Genetics, McGill University, Montreal, QC, Canada, ⁵Gerald Bronfman Department of Oncology, McGill University, Montreal, QC, Canada, ⁶Department of Anatomy and Cell Biology, McGill University, Montreal, QC, Canada, ⁷Department of Biomedical Engineering, McGill University, Montreal, QC, Canada

Synopsis

Keywords: Biomarkers, preclinical image analysis, myelin water imaging; multi-echo gradient recalled echo; multi-echo spin echo; microstructure; myelin;

Motivation: Accurately measuring myelin content in the brain is essential for understanding neurodevelopment and neuroinflammatory conditions. Traditional myelin imaging techniques, like multi-echo spin echo (MESE), are effective but can require long scan times.

Goal(s): This study aimed to evaluate whether multi-echo gradient echo (mGRE) could reliably measure myelin water fraction (MWF) and serve as an alternative to MESE.

Approach: We used mGRE and MESE imaging to assess MWF in wild-type and hypomyelinated mouse models. Comparisons were made using histological myelin markers as gold standard measures of myelin.

Results: mGRE-derived MWF results were in excellent agreement with those obtained using MESE.

Impact: This study establishes mGRE-based MWF as a reliable alternative to MESE, offering shorter scan times and improved resolution for myelin imaging in preclinical models. It advances the potential of myelin water imaging in translational research and future clinical applications.

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