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Abstract #0822

Magnetic Resonance Elastography Detects Whole Brain Stiffness Reductions during Acute Bacterial-Induced Neuroinflammation

Sabrina S. Vander Wiele1, Lance Tyler Williams1, Katrina A Milbocker1, Emma D Zarate1,2, Anna Y Klintsova2, and Curtis L Johnson1,2
1Biomedical Engineering, University of Delaware, Newark, DE, United States, 2Psychological and Brain Sciences, University of Delaware, Newark, DE, United States

Synopsis

Keywords: Biology, Models, Methods, Neuroinflammation

Motivation: Infections that can trigger acute neuroinflammation have been linked to increased risk for neurodegenerative diseases. It is unknown whether bacterial-induced acute neuroinflammation has short-term effects on brain mechanical properties during sickness and after recovery.

Goal(s): Evaluate the changes in mechanical properties of the whole brain during peak sickness and post-recovery caused by lipopolysaccharide-induced acute neuroinflammation.

Approach: A rat MR elastography protocol measuring tissue deformation to determine stiffness and relative viscosity was used to identify changes to mechanical properties.

Results: Acute neuroinflammation caused a significant decrease in whole brain stiffness during peak sickness which returned to baseline post-recovery. Relative viscosity was not significantly affected.

Impact: This study is the first to quantify the brain mechanical response due to bacterial infection-induced acute neuroinflammation. These results may be useful in understanding the connection between acute neuroinflammatory events and the onset of neurodegenerative disease.

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