Abstract #0827

Resting-state functional connectivity in mouse cervical spinal cord at 15.2T

Tzu-Wei Lee^1,2, Feng Wang^2,3, Anirban Sengupta^2,3, Arabinda Mishra^2,3, Li Min Chen ^2,3, and John C. Gore^2,3

¹Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ²Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, ³Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States

Synopsis

Keywords: Small Animals, Spinal Cord

Motivation: Resting-state functional connectivity in mice spinal cord has not been reported previously

Goal(s): To identify resting-state functional circuits within the spinal cord of mice

Approach: We used 15.2T MRI to detect the intrinsic BOLD signals in mouse spinal cords and calculated inter-voxel correlations in a resting state to delineate networks

Results: We found resting-state functional circuits were robustly detectable within gray matter in the mouse spinal cord similar to those reported for other species.

Impact: This work shows the potential to detect BOLD signals in mouse spinal cords and derive network characteristics in mouse models of different disorders.

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