Abstract #0838

Restoring Motor and Cognitive Functions with Dentate Nucleus DBS through Enhancing Brain Functional Connectivity in PTI-Induced Stroke Model

Ssu-Ju Li¹, Ching-Wen Chang^1,2, Yao-Wen Liang¹, Ting-Chieh Chen¹, Cheng-Ru Yang¹, Yu-Chun Lo³, Sheng-Huang Lin^4,5, and You-Yin Chen^1,3

¹Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei City, Taiwan, ²Biomedical Translation Research Center, Academia Sinica, Taipei City, Taiwan, ³PhD Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University, Taipei City, Taiwan, ⁴Department of Neurology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien County, Taiwan, ⁵Department of Neurology, School of Medicine, Tzu Chi University, Hualien County, Taiwan

Synopsis

Keywords: Small Animals, Stroke

Motivation: Stroke often leads to persistent motor and cognitive impairments, with limited options for effective rehabilitation.

Goal(s): To evaluate the efficacy of dentate nucleus deep brain stimulation (DN DBS) in enhancing functional recovery in a PTI-induced stroke mouse model.

Approach: MR-compatible neural probes were used to perform DN DBS. Therapeutic outcomes were assessed through behavioral tests for motor and cognitive function, along with functional MR imaging.

Results: DN DBS significantly improved motor and cognitive abilities in the PTI stroke model, as confirmed by behavioral metrics and neuroimaging markers.

Impact: This study highlights DN DBS as a potential therapeutic intervention for post-stroke rehabilitation, bridging preclinical insights to clinical applications for improved patient outcomes.

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