Keywords: Small Animals, Translational Studies, TMS, Transcranial Magnetic Stimulation, CBV, MEP, I-O curve
Motivation: TMS has been cleared by FDA for treating various neuropsychiatric disorders, but its mechanisms remain poorly understood.
Goal(s): This study aims to: i) create a rat model mimicking longitudinal TMS condition in humans; ii) image brain activity resulting from longitudinal TMS.
Approach: Healthy adult rats (N=33) underwent daily single-session high-density theta burst stimulation (hdTBS) with a focal TMS coil for 5 days. Cortical excitability and basal brain activity were probed by measuring motor-evoked potential (MEP) and basal CBV.
Results: Compared with the sham condition, hdTBS for 5 days significantly enhanced basal CBV and MEP signal.
Impact: This is the first awake rat model that replicates the focality and temporal patterns of TMS conditions in humans, opening a novel platform further investigating TMS-induced neuroplasticity.
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