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Abstract #0839

CBV mapping reveals regional brain activity changes in rats following longitudinal focal Transcranial Magnetic Stimulation (TMS)

Charlotte Qiong Li1,2, Samantha Hoffman2, Hieu Nguyen2, Antonia Vrana2, Aidan Carney2, Ying Duan2, Zilu Ma2, Nanyin Zhang1, Yihong Yang2, and Hanbing Lu2
1The Pennsylvania State University, University Park, PA, United States, 2National Institute on Drug Abuse. NIH, Baltimore, MD, United States

Synopsis

Keywords: Small Animals, Translational Studies, TMS, Transcranial Magnetic Stimulation, CBV, MEP, I-O curve

Motivation: TMS has been cleared by FDA for treating various neuropsychiatric disorders, but its mechanisms remain poorly understood.

Goal(s): This study aims to: i) create a rat model mimicking longitudinal TMS condition in humans; ii) image brain activity resulting from longitudinal TMS.

Approach: Healthy adult rats (N=33) underwent daily single-session high-density theta burst stimulation (hdTBS) with a focal TMS coil for 5 days. Cortical excitability and basal brain activity were probed by measuring motor-evoked potential (MEP) and basal CBV.

Results: Compared with the sham condition, hdTBS for 5 days significantly enhanced basal CBV and MEP signal.

Impact: This is the first awake rat model that replicates the focality and temporal patterns of TMS conditions in humans, opening a novel platform further investigating TMS-induced neuroplasticity.

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Keywords