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Abstract #0851

Feasibility of Ultra- Low-Field MRI for Measurement of Regional Infant Brain Volumes in Structures Associated with Anaemia

Jessica E. Ringshaw1,2,3, Niall J. Bourke3, Michal R. Zieff1, Catherine J. Wedderburn1,2,4, Chiara Casella5,6, Layla E. Bradford1,2, Simone R. Williams1,2, Donna Herr1, Marlie Miles1, Jonathan O’Muircheartaigh5,6,7, Carly Bennallick3, Dan J. Stein2,8, Daniel C. Alexander9, Derek K. Jones10, Steven C.R. Williams3, and Kirsten A. Donald1,2
1Department of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa, 2Neuroscience Institute, University of Cape Town, Cape Town, South Africa, 3Centre for Neuroimaging Sciences, Department of Neuroimaging, Kings College London, London, United Kingdom, 4Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, United Kingdom, 5Department for Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, United Kingdom, 6Research Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, Kings College London, London, United Kingdom, 7MRC Centre for Neurodevelopmental Disorders, Kings College London, London, United Kingdom, 8SA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, University of Cape Town, Cape Town, South Africa, 9Centre for Medical Image Computing, Department of Computer Science, University College London, London, South Africa, 10Cardiff University Brain Imaging Research Centre, Cardiff University, Cardiff, United Kingdom

Synopsis

Keywords: Neuro, Validation, Antenatal Maternal Anaemia, Child Brain Development, Infant Brain Volume, High-Field MRI, Ultra- Low-Field MRI, Low- and Middle-Income Country

Motivation: The extent to which ultra- low-field MRI can detect the impact of antenatal maternal anaemia on child brain structure is unknown, particularly in infants.

Goal(s): To assess the comparability of ultra-low (64mT) and high-field (3T) volumes in infants from the Khula South Africa birth cohort for brain regions associated with maternal anaemia.

Approach: Correlations and concordance coefficients were used to investigate associations between ultra-low and high-field infant brain volumes for the corpus callosum, caudate, and putamen.

Results: Findings demonstrated a strong linear association and a high degree of concordance between ultra-low and high-field regional brain volumes in infants between 3-24 months of age.

Impact: This study demonstrates high comparability between ultra- low-field (64mT) and high-field (3T) volumes for brain regions implicated in antenatal maternal anaemia. Findings validate the use of the Hyperfine scanner for paediatric neuroimaging work on anaemia across low- and middle-income countries.

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Abstract

Keywords