Abstract #0862

Quantitative evaluation of neurocutaneous melanosis using 3D MR fingerprinting

Masaki Umehana¹, Yasutaka Fushimi¹, Michiharu Sakamoto², Takeshi Yoshida³, Sachi Okuchi¹, Sayo Otani¹, Akihiko Sakata¹, Takayuki Yamamoto¹, Satoshi Nakajima¹, Satoshi Ikeda¹, Shuichi Ito¹, Yongping Ma¹, Shin Morooka¹, Naoki Morimoto², and Yuji Nakamoto¹

¹Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan, ²Department of Plastic and Reconstructive Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan, ³Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan

Synopsis

Keywords: Rare Disease, MR Fingerprinting, neurocutaneous melanosis

Motivation: To quantitatively evaluate neurocutaneous melanosis (NCM) abnormalities using T1- and T2-relaxation times from 3D MR fingerprinting (MRF).

Goal(s): To develop a novel tool for evaluating NCM lesions on 3D MRF.

Approach: Regions of interests (ROIs) were manually placed on the amygdala and other melanosis lesions, including the cerebellum and thalamus, on T1- and T2-mappings from MRF and then on T1-weighted imaging (T1WI). For normalization, T1 intensity ratios to the middle cerebellar peduncles were calculated on T1WI.

Results: Melanosis-positive areas had significantly lower T1 min values, indicating that the minimum T1 value threshold for detecting melanosis may be approximately 1000 ms.

Impact: This study introduces a quantitative MR fingerprinting method for assessing neurocutaneous melanosis (NCM), improving diagnostic accuracy and objectivity, and supporting early, precise identification of melanosis, which may enhance understanding and management of NCM.

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