Meeting Banner
Abstract #0888

Multi-resolution hyperpolarized 13C EPI with atlas-based prescription for metabolic imaging of human gliomas

Adam W Autry1, Jeremy W Gordon1, Hsin-Yu Chen1, Yaewon Kim1, Javier Villanueva-Meyer1, Susan M Chang2, Jennifer Clarke2, Nancy A Oberheim-Bush2, Duan Xu1, Janine M Lupo1, Peder EZ Larson1, Daniel Vigneron1,2,3, and Yan Li1
1Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, United States, 3Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, United States

Synopsis

Keywords: Tumors (Post-Treatment), Hyperpolarized MR (Non-Gas), gliomas, metabolism

Motivation: To improve the glycolytic assessment of patients with gliomas.

Goal(s): Increase the resolution of hyperpolarized 13C neuroimaging and incorporate techniques for serial monitoring of metabolism.

Approach: This study implemented a multi-resolution EPI sequence with a 4-fold increase in the resolution of the metabolic probe [1-13C]pyruvate, while utilizing automatic atlas-based prescription for consistent volumetric coverage. Multi- and constant-resolution EPI acquisitions were compared in 5 subjects (1 volunteer, 4 patients with glioblastomas) alongside kinetic modeling of pyruvate-to-lactate conversion (kPL).

Results: The multi-resolution EPI demonstrated superior characterization of pyruvate perfusion in lesions and vessels, reducing partial volume effects and improving the assessment of metabolism from kPL.

Impact: This project improved the assessment of glycolytic metabolism in patients with gliomas using multi-resolution EPI that provides a 4-fold increase in hyperpolarized [1-13C]pyruvate resolution, while also leveraging automatic atlas-based prescription for consistent volumetric coverage.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords