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Abstract #0889

A REnal Flow and Microstructure AnisotroPy (REFMAP) MR assessment of renal function: comparison with measured glomerular filtration rate

Nima Gilani1, Nalini Jeet1, William C Huang2, Vasishta S Tatapudi3, Fang-Ming Deng4, Kent Friedman5, Karolina Soltys5, Mary Bruno1, Malika Kumbella1, Shavy Nagpal6, Hersh Chandarana1, and Eric E. Sigmund1
1Center for Advanced Imaging Innovation and Research, Department of Radiology, NYU Langone Health, New York, NY, United States, 2Department of Urology and Radiology, NYU Langone Health, New York, NY, United States, 3NYU Langone Transplant Institute, NYU Langone Health, New York, NY, United States, 4Department of Urology, NYU Langone Health, New York, NY, United States, 5Department of Radiology, NYU Langone Health, New York, NY, United States, 6NYC Health and Hospitals, New York, NY, United States

Synopsis

Keywords: IVIM, IVIM, Renal, Kidney function

Motivation: Monitoring and predicting stability of bilateral renal function is necessary for renal cancer patients. Estimated glomerular filtration rate (eGFR), from serum creatinine, provides an estimate of renal function without considering laterality and has demographic biases and limited accuracy. Alternatively, the measured GFR (mGFR) provides more accurate measures of renal function but requires injection of radioactive tracers.

Goal(s): We tested the performance of an advanced diffusion-weighted MRI method as a non-invasive alternative for renal function assessment.

Approach: Quantitative diffusion-weighted parameters and kidney volumes were used to estimate renal function in renal cancer patients.

Results: The MR estimates highly correlated with mGFR of individual kidneys.

Impact: We present a diffusion-weighted MR method to assess the function of individual kidneys in a cohort of kidney cancer patients. The technique outputs accurate information complementary to routinely used estimated glomerular filtration rate (eGFR).

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Keywords