Abstract #0890

Differentiating Benign and Malignant Thyroid Nodules Using Time-Dependent Diffusion MRI

Huanhuan Ren¹, Zongshu Wang², Jiuquan Zhang¹, Diwei Shi³, Daihong Liu¹, Hua Guo⁴, Junzhong Xu^5,6,7,8, Junhao Huang¹, Hong Yu¹, Yong Tan¹, and Ting Yin⁹

¹Chongqing University Cancer Hospital, Chongqing, China, ²Tanwei College,Tsinghua University, Beijing, China, ³Center for Nano and Micro Mechanics, Department of Engineering Mechanics, Tsinghua University, Beijing, China, ⁴Center for Biomedical Imaging Research, School of Biomedical Engineering, Tsinghua University, Beijing, China, ⁵Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, ⁶Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, ⁷Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ⁸Department of Physics and Astronomy, Vanderbilt University, Nashville, TN, United States, ⁹MR Collaborations, Siemens Healthineers, Chengdu, China

Synopsis

Keywords: Biology, Models, Methods, Cancer

Motivation: The differential diagnosis between benign and malignant thyroid nodules is crucial for treatment planning and prognostic evaluation. However, there is no ideal method for distinguishing thyroid nodules.

Goal(s): To investigates whether microstructural parameters from time-dependent diffusion MRI (td-dMRI) can distinguish between benign and malignant thyroid lesions.

Approach: Thirty-two patients with thyroid nodules underwent td-dMRI prior to treatment. Microstructural parameters were fitted using the IMPULSED model for statistical analysis.

Results: The combined model based on td-dMRI showed high performance to select malignant lesions from benign thyroid nodules.

Impact: The combined model integrating apparent diffusion coefficient and microstructural parameters microstructural parameters based on td-dMRI holds potential to differentiate between benign and malignant thyroid nodules. This distinction is critically important for the diagnosis and management of thyroid nodules.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.