Abstract #0910

Non-contrast free-breathing pulmonary perfusion imaging using VSASL

Ke Zhang^1,2, Simon M. F. Triphan^1,2, Carley Stewart^1,2, Oliver Sedlaczek^1,3, Christian H. Ziener³, Mark E. Ladd⁴, Heinz-Peter Schlemmer³, Hans-Ulrich Kauczor^1,2, and Mark O. Wielpütz^1,2

¹Department of Diagnostic and Interventional Radiology, Heidelberg University Hospital, Heidelberg, Germany, ²Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany, ³Division of Radiology, German Cancer Research Center, Heidelberg, Germany, ⁴Division of Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany

Synopsis

Keywords: Lung, Perfusion

Motivation: Quantitative regional pulmonary blood flow (PBF) is a diagnostically useful parameter since in the lungs regional perfusion is regulated by hypoxic pulmonary vasoconstriction.

Goal(s): Due to the high costs of gadolinium-based contrast agents and safety issues contrast-free imaging technique such as arterial spin labelling (ASL) is interesting, especially for repeated measurements or applications in children.

Approach: In this study, we aim to develop a robust velocity selective ASL (VSASL) sequence with unbalanced steady-state free-precession (ubSSFP)-readout for free-breathing perfusion measurement of the lung parenchyma.

Results: This study shows the feasibility of non-contrast free-breathing pulmonary perfusion imaging using VSASL.

Impact: This study developed a robust VSASL sequence with unbalanced steady-state free-precession (ubSSFP)-readout for free-breathing perfusion measurement of the lung parenchyma. The approach remains to be applied and examined further in patients with lung disease.

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