Keywords: Lung, Hyperpolarized MR (Gas), Healthy lung
Motivation: There is a limited understanding of multi-site comparability of Hyperpolarized 129Xe MRI (Xe-MRI).
Goal(s): To better understand variability of Xe-MRI across sites, we examine preliminary results from ventilation, diffusion-weighted, and gas exchange Xe-MRI in 64 healthy young adults from the Lung Health Cohort.
Approach: 3 of 5 designated sites have enrolled and imaged 64 participants following 129Xe MRI Clinical Trials Consortium recommended protocols. Images have been compared across sites to assess preliminary multi-site comparability of data.
Results: Preliminary analysis indicates strong cross-site comparability in Ventilation and Gas Exchange Xe-MRI. Diffusion-weighted images appear to be less well harmonized.
Impact: Trials using xenon MRI have been hampered by an incomplete understanding of normal variation across sites. In this preliminary analysis, we will examine the 3 major Xe-MRI contrasts (ventilation, diffusion-weighted, gas exchange) in 64 healthy volunteers imaged across three sites.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords