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Abstract #0913

XeLHC: Harmonized Acquisition of Ventilation, Diffusion, and Gas Exchange 129Xe MRI At 3 Sites in the Lung Health Cohort

Ivina Mali1, Mario Castro1, David Mummy2, Bastiaan Driehuys2, Loretta Que2, Sean Fain3, Andrew Hahn3, Alejandro Comellas3, and Peter Niedbalski1
1Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, United States, 2Duke University, Durham, NC, United States, 3University of Iowa Health Care, Iowa City, IA, United States

Synopsis

Keywords: Lung, Hyperpolarized MR (Gas), Healthy lung

Motivation: There is a limited understanding of multi-site comparability of Hyperpolarized 129Xe MRI (Xe-MRI).

Goal(s): To better understand variability of Xe-MRI across sites, we examine preliminary results from ventilation, diffusion-weighted, and gas exchange Xe-MRI in 64 healthy young adults from the Lung Health Cohort.

Approach: 3 of 5 designated sites have enrolled and imaged 64 participants following 129Xe MRI Clinical Trials Consortium recommended protocols. Images have been compared across sites to assess preliminary multi-site comparability of data.

Results: Preliminary analysis indicates strong cross-site comparability in Ventilation and Gas Exchange Xe-MRI. Diffusion-weighted images appear to be less well harmonized.

Impact: Trials using xenon MRI have been hampered by an incomplete understanding of normal variation across sites. In this preliminary analysis, we will examine the 3 major Xe-MRI contrasts (ventilation, diffusion-weighted, gas exchange) in 64 healthy volunteers imaged across three sites.

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Keywords