Abstract #0925

Evaluation of MR Fingerprinting for Prostatic Lesion Characterization in the Peripheral Zone with Histopathology from MR-TRUS Fusion Biopsy

Zhiqing Yin¹, Sohrab Afshari Mirak², Dheeman Futela², Chris A. Flask³, Leonardo Kayat Bittencourt^2,3, Mark Griswold^1,3, Sree Harsha Tirumani^2,3, and Yong Chen³

¹Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ²Radiology, University Hospitals Cleveland Medical Center, Cleveland, OH, United States, ³Radiology, Case Western Reserve University, Cleveland, OH, United States

Synopsis

Keywords: Prostate, Quantitative Imaging

Motivation: Accurate image-based characterization of prostate lesions in the peripheral zone is critical for patient management and biopsy decision making.

Goal(s): To evaluate the utility of MRF for characterizing prostatic lesions validated with MR-TRUS fusion biopsy.

Approach: MRF-derived T₁ and T₂ values were combined with standard ADC assessment to characterize prostate lesions in the peripheral zone. The accuracy was evaluated with MR-TRUS fusion biopsy as the ground truth.

Results: Lesion characterization using all three tissue properties (T₁, T₂, and ADC) provided the highest accuracy in differentiation of clinically significant prostate cancer from low-grade prostate cancer and benign lesions.

Impact: The results from this study demonstrate the potential role of magnetic resonance fingerprinting as a quantitative imaging tool for differentiating clinically significant prostate cancers to provide critical information and increase confidence in subsequent biopsy decision-making.

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