Abstract #0926

High-resolution quantitative imaging of the inner ear using 3D Magnetic Resonance Fingerprinting

Jannik Stebani^1,2, Ivaylo Angelov¹, Peter Dawood¹, Tom Griesler³, Petra Albertova^1,4, Thomas Kampf^1,5, Kristen Rak⁶, Peter Michael Jakob¹, Martin Blaimer², and Maximilian Gram^1,4

¹Experimental Physics 5, University of Würzburg, Würzburg, Germany, ²Magnetic Resonance and X-Ray Imaging Department, Division Development Center X-Ray Technology, Fraunhofer Institute for Integrated Circuits IIS, Würzburg, Germany, ³Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States, ⁴Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany, ⁵Department of Diagnostic and Interventional Neuroradiology, University Hospital Würzburg, Wuerzburg, Germany, ⁶Department of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery and the Comprehensive Hearing Center, University Hospital Würzburg, Würzburg, Germany

Synopsis

Keywords: MR Fingerprinting, MR Fingerprinting, inner ear, cochlea, segmentation, low-rank

Motivation: Quantitative high-resolution mapping of the inner ear (IE) can potentially elucidate pathologies (e.g. hearing loss, vertigo) that elude manifestation in conventional images.

Goal(s): Addressing the shortage in literature concerning quantitative methods for IE, we targeted the development of a 3D multiparametric mapping sequence with 500µm isotropic resolution to capture delicate microanatomy and relaxometric information.

Approach: With the developed high resolution, volumetric Magnetic Resonance Fingerprinting sequence, we measured synthetic IE fluids and in-vivo.

Results: The method successfully generated high-resolution quantitative maps. Compared to in-vivo, synthetic fluids exhibited longer T₂values. Aggregate relaxometric results for manually segmented fluid reservoirs were consistent with existing sparse literature.

Impact: High-resolution 3D imaging of the IE with joint morphometry and relaxometry as demonstrated in this preliminary work has the potential to supplant the collection of existing methods and may help to better elucidate IE pathologies with non-shape altering, inflammatory etiologies.

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