Meeting Banner
Abstract #0975

IDEAL-IQ and BOLD MRI Assessment of Testosterone and Resistance Training Effects on Fat Infiltration and Blood Perfusion in Sarcopenic Rats

Xiaoling kui1, Xincheng Huang1, Yilong Huang1, Lisha Nie2, and Bo He1
1The First Affiliated Hospital of Kunming Medical University, Kunming, China, China, 2GE HealthCare MR Research, Beijing, China, Beijing, China

Synopsis

Keywords: Muscle, Skeletal

Motivation: Loss of muscle mass in sarcopenia leads to increased fat infiltration and reduced perfusion. The effects of resistance training (RT) and testosterone (T) propionate on these changes remain unclear.

Goal(s): This study evaluates how RT combined with T propionate impacts fat infiltration and perfusion in a sarcopenic rat model.

Approach: A controlled animal study with RT, T propionate, and combined treatments were conducted. IDEAL-IQ and BOLD MRI measured PDFF and R2* values, with histological validation.

Results: The RT+T combination significantly improved grip strength, endurance, and muscle CSA, while reducing PDFF and R2* values, indicating enhanced muscle quality.

Impact: This combined RT and T treatment demonstrates a potential therapeutic approach for sarcopenia, effectively enhancing muscle structure and function. IDEAL-IQ and BOLD MRI offer reliable, noninvasive methods for tracking these muscle changes in research and clinical settings.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords