Keywords: Muscle, Skeletal
Motivation: Loss of muscle mass in sarcopenia leads to increased fat infiltration and reduced perfusion. The effects of resistance training (RT) and testosterone (T) propionate on these changes remain unclear.
Goal(s): This study evaluates how RT combined with T propionate impacts fat infiltration and perfusion in a sarcopenic rat model.
Approach: A controlled animal study with RT, T propionate, and combined treatments were conducted. IDEAL-IQ and BOLD MRI measured PDFF and R2* values, with histological validation.
Results: The RT+T combination significantly improved grip strength, endurance, and muscle CSA, while reducing PDFF and R2* values, indicating enhanced muscle quality.
Impact: This combined RT and T treatment demonstrates a potential therapeutic approach for sarcopenia, effectively enhancing muscle structure and function. IDEAL-IQ and BOLD MRI offer reliable, noninvasive methods for tracking these muscle changes in research and clinical settings.
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