Abstract #0976

Investigation of the feasibility of CEST MRI in early detecting diabetic muscle injuries in a rabbit model at 5 T

Qiting Wu¹, Zhongyichen Huang², Hao Tang^1,3, and Yin Wu¹

¹Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China, ²Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, ³School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong, China

Synopsis

Keywords: Muscle, CEST & MT

Motivation: Although CEST MRI has been increasingly used in muscle energy metabolism imaging, its ability in early detecting diabetic muscle impairment remains elucidated.

Goal(s): To investigate the feasibility of CEST MRI in early detecting diabetic skeletal muscle injuries.

Approach: Six rabbits were scanned with T₂w and CEST MRI before and 2, 4, 6, and 8 weeks following diabetes mellitus model induction. Alterations of phosphocreatine (PCr) and creatine (Cr), and their ratio with time were evaluated.

Results: Muscle structures showed no apparent abnormalities. CrCEST signals significantly increased in week 2, whereas PCrCEST signals remained constant over time, leading to significantly reduced PCr/Cr in week 6.

Impact: The significantly increased Cr and reduced PCr/Cr occurred before structural alterations, suggesting the feasibility of CEST MRI in early detecting diabetic muscle damage at the energy metabolism level.

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