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Abstract #0980

Relationship between function and MRI biomarkers in tongue muscles

Eléonore Vermeulen1, Pierre-Yves Baudin1, Yves Fromes1, Béatrice Matot1, Eric Giacomini1, Marc Lapert2, Jean-Yves Hogrel3, and Benjamin Marty1
1Neuromuscular Investigation Center, NMR Laboratory, Institute of Myology, Paris, France, 2Siemens Healthcare, Courbevoie, France, 3Neuromuscular Investigation Center,Neuromuscular Physiology and Evaluation Lab, Insitute of Myology, Paris, France

Synopsis

Keywords: Muscle, Quantitative Imaging

Motivation: Fat fraction and water-T2 have been identified as biomarkers of muscle tissue alterations in neuromuscular diseases and are linked to functional outcomes. Several muscle disorders implicate tongue muscles, yet due to the swallowing movement, quantitative MRI is rarely applied at this level.

Goal(s): In this feasibility study, we proposed an application of quantitative MRI to tongue muscles.

Approach: We combined functional evaluation of the muscle combined with an RF phase-modulated gradient-echo acquisition with 3D radial encoding to obtain FF and water T2 maps

Results: There was a high but non-significant correlation betweenT2H2O and tongue strength in healthy volunteers.

Impact: The use of quantitative fat fraction and water T2 imaging in tongue muscles in addition to functional testing represents a promising approach for evaluating these muscles.

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