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Abstract #0981

Multifidus muscle mitochondria function in those with non-specific chronic low back pain

Daniel Cawley1, Seyedeh Nasim Adnani 2, Adam Tickal1, Thomas Denney2, and Adil Bashir2
1Anatomical Sciences, Edward Via College of Osteopathic Medicine, Auburn, AL, United States, 2Electrical and Computer Engineering, Auburn Univeristy, Auburn, AL, United States

Synopsis

Keywords: Muscle, Spectroscopy, 31P, Multifidus muscle, Lower back pain, Energetics

Motivation: Inhibition or weakness of the multifidus muscle caused by mitochondrial function may lead to chronic low back pain, often diagnosed as “non-specific.”

Goal(s): Develop methodology to measure lumbar multifidus muscle’s mitochondrial function using 31P MRS. Compare multifidus muscle mitochondrial function in individuals with and without low back pain (LBP).

Approach: Implemented MRI safe EMS based approach to stimulate multifidus muscle. Mitochondrial oxidative capacity (Qmax) was significantly lower in the LBP individuals compared to healthy individuals.

Results: Mitochondrial oxidative capacity (Qmax) was significantly lower in the LBP individuals compared to healthy individuals.

Impact: We, for the first time, demonstrated the application of 31P MRS for measurement of mitochondrial function in lumbar multifidus muscle. Impaired ATP production in weak/underused multifidus muscle might be early markers of unspecified lower back pain.

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