Keywords: Traumatic Brain Injury, Brain
Motivation: Traumatic brain injury(TBI) is a major cause of dementia, however neuroimaging biomarkers remain underinvestigated. Although choroid plexus volume(CPV) is promising, its relationship with TBI is unclear.
Goal(s): This study aims to elucidate changes in CPV in TBI patients and its relationship with cognitive function.
Approach: We analyzed UK Biobank data, comparing CPV, total gray matter volume(GMV), and white matter volume(WMV) between 991 TBI-experienced individuals and 991 controls, also using mediation analysis.
Results: Increased CPV and decreased GMV were found in TBI patients. CPV significantly mediated TBI's impact on cognitive function, while GMV and WMV did not show significant effects.
Impact: Our findings suggest that choroid plexus volume could be a sensitive biomarker for TBI-related cognitive decline. This may contribute to developing novel therapeutic strategies targeting the choroid plexus and enable better prediction for TBI-related cognitive dysfunction.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords