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Abstract #1000

Choroid Plexus Enlargement Mediates Cognitive Decline in Traumatic Brain Injury: UK Biobank Study

Yuichi Morita1,2, Koji Kamagata1, Moto Nakaya1,2, Kaito Takabayashi1, Christina Andica3, Junko Kikuta1, Toshiaki Akashi1, Akihiko Wada1, Osamu Abe2, and Shigeki Aoki1,3
1Department of Radiology, Juntendo university, Tokyo, Japan, 2Department of Radiology, The University of Tokyo, Tokyo, Japan, 3Faculty of Health Data Science, Juntendo university, Chiba, Japan

Synopsis

Keywords: Traumatic Brain Injury, Brain

Motivation: Traumatic brain injury(TBI) is a major cause of dementia, however neuroimaging biomarkers remain underinvestigated. Although choroid plexus volume(CPV) is promising, its relationship with TBI is unclear.

Goal(s): This study aims to elucidate changes in CPV in TBI patients and its relationship with cognitive function.

Approach: We analyzed UK Biobank data, comparing CPV, total gray matter volume(GMV), and white matter volume(WMV) between 991 TBI-experienced individuals and 991 controls, also using mediation analysis.

Results: Increased CPV and decreased GMV were found in TBI patients. CPV significantly mediated TBI's impact on cognitive function, while GMV and WMV did not show significant effects.

Impact: Our findings suggest that choroid plexus volume could be a sensitive biomarker for TBI-related cognitive decline. This may contribute to developing novel therapeutic strategies targeting the choroid plexus and enable better prediction for TBI-related cognitive dysfunction.

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