Abstract #1001

Investigation of the Association Between Choroid Plexus Volume Alterations and Cognitive Impairment in Type 2 Diabetes Mellitus

Fushuai Zhang¹, Zhenyu Cheng¹, Yuanyuan Wang¹, Na Wang², Xinyue Zhang², Pengcheng Liang², Yiwen Chen², Xinxin Huo², Boyao Chen², Jiaxiang Xin³, Meng Li⁴, Changhu Liang², and Lingfei Guo^1,2

¹School of Medical Imaging, Binzhou Medical University, Yantai, China, ²Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China, ³MR Research Collaboration, Siemens Healthineers, Shanghai, China, Shanghai, China, ⁴Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany

Synopsis

Keywords: Neurotransmission, Brain, Choroid Plexus Volume, Cognitive Impairment, High-density Lipoprotein, Type 2 Diabetes Mellitus, Magnetic Resonance Imaging

Motivation: Assessing choroid plexus volume (CPV) in type 2 diabetes mellitus (T2DM) is valuable for detecting early indicators of cognitive decline and understanding how metabolic factors affect brain health, supporting timely intervention for those at risk.

Goal(s): To determine the relationship between CPV and cognitive function in T2DM patients versus healthy individuals, while also assessing the impact of metabolic markers like high-density lipoprotein (HDL) on CPV.

Approach: A prospective cohort study

Results: As HDL levels decrease, choroid plexus volume increases, potentially impairing normal executive function and information processing speed.

Impact: This study highlights the essential role of HDL in regulating choroid plexus volume and cognitive function, offering new avenues for future research.

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