Abstract #1003

The relationship between the choroid plexus volume and cerebral microbleeds in the lobar locations: A large cohort study

Kana Saito¹, Keita Watanabe ², Sera Kasai³, Yuka Ishimoto³, Tomohiro Shintaku³, Amo Ozawa³, Mizuki Imura³, Taiki Koshiishi³, Tatsuya Mikami⁴, Yoshinori Tamada⁴, and Shingo Kakeda³

¹Department of Radiology, Hirosaki University School of Medicine, Hirosakicity, Japan, ²Department of Radiology, Kyoto Prefectural University of Medicine, Kyoto, Japan, ³Department of Radiology, Hirosaki University School of Medicine, Hirosaki, Japan, ⁴Inovation Center for Health Promotion, Graduate School Of Medicine, Hirosaki University, Hirosaki, Japan

Synopsis

Keywords: Neurofluids, Alzheimer's Disease, cerebrospinal fluid

Motivation: Lobar cerebral microbleeds (CMBs) are linked to cerebral amyloid angiopathy (CAA). Evidence indicates impaired cerebrospinal fluid (CSF) clearance in CAA, but large-scale studies on CMBs and CSF clearance parameters are lacking.

Goal(s): To investigate if lobar CMBs are associated with MRI markers of impaired CSF clearance, specifically increased choroid plexus volume (CPV), enlarged perivascular spaces (EPVS), and increased lateral ventricle volume (LVV).

Approach: This cross-sectional study included 2,082 elderly participants. MRI data, including CPV, EPVS, and LVV, were analyzed

Results: Lobar CMBs correlated with CPV, suggesting CSF clearance impairment, while deep CMBs showed no association.

Impact: This study found a significant association between lobar CMBs and CPV in a large elderly population, including healthy individuals and those with mild cognitive impairment (MCI), suggesting the potential clinical relevance of lobar CMBs in MCI and asymptomatic groups.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.