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Abstract #1004

Association between choroid plexus features, AD pathology, and cognitive impairment in non-demented participants: a longitudinal study

Miao Lin1, Lingyun Liu1, Hui Hong1, and Peiyu Huang1
1Department of Radiology, The 2nd Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

Synopsis

Keywords: Alzheimer's Disease, Alzheimer's Disease, Choroid plexus

Motivation: Choroid plexus (ChP) disruption may contribute to the progression of Alzheimer’s disease (AD).

Goal(s): To explore whether ChP structural features are associated with AD pathology and cognitive decline.

Approach: Volumetric, shape, and texture ChP features were extracted for correlation and mediation analysis. Longitudinal analysis was performed using a linear mixed model.

Results: ChP features were associated with AD pathology, mediated its relationship with cognition, and predicted cognitive decline over time.

Impact: Our findings provide a detailed description of ChP structural alterations due to AD pathology, potentially leading to cognitive impairment over time in patients with AD.

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