Keywords: Alzheimer's Disease, Alzheimer's Disease, Choroid plexus
Motivation: Choroid plexus (ChP) disruption may contribute to the progression of Alzheimer’s disease (AD).
Goal(s): To explore whether ChP structural features are associated with AD pathology and cognitive decline.
Approach: Volumetric, shape, and texture ChP features were extracted for correlation and mediation analysis. Longitudinal analysis was performed using a linear mixed model.
Results: ChP features were associated with AD pathology, mediated its relationship with cognition, and predicted cognitive decline over time.
Impact: Our findings provide a detailed description of ChP structural alterations due to AD pathology, potentially leading to cognitive impairment over time in patients with AD.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords