Abstract #1011

Quantification of cerebral cortical displacement driven by visual stimulation using motion-encoded stimulated-echo EPI at 7T

Amelia Strom^1,2, Timothy G. Reese^2,3, Laura D. Lewis^2,4, and Jonathan R. Polimeni^1,2,3

¹Harvard-MIT Program in Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States, ²Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ³Department of Radiology, Harvard Medical School, Boston, MA, United States, ⁴Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States

Synopsis

Keywords: Neurofluids, High-Field MRI, Brain, Velocity & Flow, fMRI Acquisition, fMRI Analysis, Neuro, Neurofluids

Motivation: Tissue motion may mediate the relationship between blood volume and CSF flow dynamics, as functional hyperemia may displace tissue; however, cortical tissue motion in response to neuronal stimulation has not yet been measured dynamically.

Goal(s): To demonstrate the feasibility of quantifying stimulation-locked tissue displacement.

Approach: We optimized a novel method for concurrent BOLD-fMRI and tissue displacement quantification based on the DENSE technique for activity-related tissue motion, and applied it in vivo with a visual stimulation paradigm.

Results: We identified patterns of tissue motion co-occurring with the onset and offset of the visual stimulus and demonstrated that patterns differ between gray matter and CSF.

Impact: Cerebral cortical tissue motion in response to neuronal activation is quantified in vivo in real-time, enabling investigations into the contributions of tissue displacement to CSF flow patterns and characterization of dynamic partial volume effects for fMRI analysis and interpretation.

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