Abstract #1019

Feasibility and Optimal b-value combination for DWI-based Virtual Elastography in assessing Chronic Kidney Disease Function

Yueyao Chen¹, Ruirui Qi¹, Junfeng Li¹, Wenxi Liu², Peiyin Luo¹, Qiuyi Chen¹, Qiumei Liang¹, Fanqi Meng¹, Haodong Qin³, Feifei Qu⁴, Yanglei Wu⁵, and Youjia Zeng¹

¹Department of Radiology, Shenzhen Traditional Chinese Medicine Hospital (The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine), Shenzhen, China, ²Medical AI Lab,School of Biomedical Engineering, Medical School, Shenzhen University, Shenzhen, China, ³MR Research Collaboration, Siemens Healthineers, Guangzhou, China, ⁴MR Research Collaboration, Siemens Healthineers, Shanghai, China, ⁵MR Research Collaboration, Siemens Healthineers, Beijing, China

Synopsis

Keywords: Kidney, Data Analysis

Motivation: The DWI-based virtual MR elastography(vMRE) is still in the research in chronic kidney disease (CKD).

Goal(s): To investigate shifted apparent diffusion coefficient (sADC) and virtual shear modulus (µ_diff) for assessing CKD renal function and determine the optimal b-value combination.

Approach: This study included 54 controls and 58 CKD patients, divided into CKD_1-3 and CKD_4-5 subgroups. 3.0T MRI with multi-b-value DWI sequence. The data were analyzed using ANOVA, Spearman, partial correlation, and receiver-operating characteristic curves, compared using DeLong's test.

Results: sADC and vMRE were effective in assessing renal function and diagnosing CKD, with b-value of 200-800 s/mm² recommended as optimal.

Impact: This study shows that virtual magnetic resonance elastography non-invasively assesses chronic kidney disease (CKD) renal function, with optimal b-values of 200-800s/mm², providing a new imaging biomarker for the clinical assessment of CKD.

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