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Abstract #1026

MRI of early myocardial ischemia in a pig model and feasibility of MR-guided balloon occlusion for real-time time ischemia imaging

Simon Reiss1, David Boll2, Timo Heidt2, Constantin von zur Muehlen2, Alexander Maier2, and Michael Bock1
1Dept. of Diagnostic and Interventional Radiology - Medical Physics, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany, 2Dept. of Cardiology and Angiology, University Heart Center Freiburg – Bad Krozingen, Faculty of Medicine, University of Freiburg, Freiburg, Germany

Synopsis

Keywords: Heart Failure, Cardiovascular

Motivation: Ischemia-reperfusion injury (IRI) in pigs is a critical area of research in cardiology, mimicking human myocardial ischemic injury and reperfusion response. Current IRI studies have shown inconsistent results.

Goal(s): To assess myocardial injury following IRI using CMR and to evaluate the feasibility of MRI-guided balloon occlusion enabling real-time ischemia monitoring.

Approach: Twenty pigs were subjected to myocardial ischemia, followed by CMR post-reperfusion. Additionally, a fully MR-guided balloon occlusion was tested in two animals monitoring ischemia in real time.

Results: Prolonged ischemia (60-90minutes) led to elevated T1 and T2 values and positive LGE. MRI-guided catheterization was feasible and enabled visualization of ischemic regions.

Impact: This study provides a detailed assessment of CMR findings of early reperfusion injury and demonstrates, that MR-guided coronary balloon occlusion is feasible. This may enabling real-time imaging of myocardial injury formation.

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