Keywords: Heart Failure, Cardiovascular
Motivation: Ischemia-reperfusion injury (IRI) in pigs is a critical area of research in cardiology, mimicking human myocardial ischemic injury and reperfusion response. Current IRI studies have shown inconsistent results.
Goal(s): To assess myocardial injury following IRI using CMR and to evaluate the feasibility of MRI-guided balloon occlusion enabling real-time ischemia monitoring.
Approach: Twenty pigs were subjected to myocardial ischemia, followed by CMR post-reperfusion. Additionally, a fully MR-guided balloon occlusion was tested in two animals monitoring ischemia in real time.
Results: Prolonged ischemia (60-90minutes) led to elevated T1 and T2 values and positive LGE. MRI-guided catheterization was feasible and enabled visualization of ischemic regions.
Impact: This study provides a detailed assessment of CMR findings of early reperfusion injury and demonstrates, that MR-guided coronary balloon occlusion is feasible. This may enabling real-time imaging of myocardial injury formation.
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