Abstract #1027

Accelerated 4D DENSE for Volumetric Myocardial Strain Imaging Using Reduced Field-of-View: A Preliminary Study

Yuxiao Wu^1,2, Sile Wang^1,2, Shu-Fu Shih¹, Siyue Li¹, Fei Han³, Kim-Lien Nguyen^1,2,4,5, J. Paul finn^1,4, and Xiaodong Zhong^1,2,4

¹Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States, ²Department of Bioengineering, Samueli School of Engineering, University of California Los Angeles, Los Angeles, CA, United States, ³Siemens Medical Solutions USA, Malvern, PA, United States, ⁴Physics and Biology in Medicine Graduate Program, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States, ⁵Division of Cardiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States

Synopsis

Keywords: Myocardium, Myocardium, Strain; DENSE

Motivation: Strain imaging provides valuable insights into myocardial mechanics, yet its practical application is limited by the prolonged acquisition time.

Goal(s): To accelerate 4D DENSE acquisitions.

Approach: The proposed accelerated DENSE protocol used reduced FOV to achieve a shorter acquisition time. Five healthy subjects underwent accelerated DENSE acquisitions with reduced FOV and reference DENSE acquisitions with full FOV.

Results: The accelerated protocol reduced the acquisition time by approximately 33%, compared to the reference protocol with the same left ventricle coverage. The accelerated protocol showed good agreement with the reference protocol for calculated strain values.

Impact: The accelerated protocol achieved a reliable 33% reduction in acquisition time compared to the reference protocol. With further optimization and validation, this proposed network may facilitate efficient 4D DENSE data acquisition for whole-heart strain imaging in clinical settings.

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