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Abstract #1033

Metabolic phenotypes and cardiac function: Insights from UK Biobank cardiac MRI and outcomes analysis

Balazs Bogner1, Matthias Jung1, Marco Reisert1,2, Juliane Maushagen1, Susanne Rospleszcz1, Janis Nolde3, Christopher Schlett1, Fabian Bamberg1, Andreas Kammerlander4, Jakob Weiss5, and Jana Taron1
1Radiology, University Medical Center Freiburg, Freiburg, Germany, 2Stereotactic and Functional Neurosurgery, University Medical Center Freiburg, Freiburg, Germany, 3Internal Medicine IV (Nephrology), University Medical Center Freiburg, Freiburg, Germany, 4Cardiology, Medical University of Vienna, Vienna, Austria, 5Radiology, University Medical Canter Freiburg, Freiburg, Germany

Synopsis

Keywords: Heart Failure, Cardiovascular, Cardiac remodeling, Metabolic phenotypes, Obesity, Population imaging, Risk stratification

Motivation: Cardiac dysfunction patterns preceding cardiovascular events in different metabolic phenotypes remain poorly understood, limiting effective risk stratification in the general population despite rising obesity and metabolic disease rates.

Goal(s): To characterize cardiac adaptation patterns across metabolic phenotypes using UK Biobank cardiac MRI data and determine their association with long-term cardiovascular outcomes.

Approach: Analysis of cardiac structure, function, and clinical outcomes in 28,897 participants stratified by metabolic health and obesity status.

Results: Metabolic phenotypes showed distinct cardiac adaptations despite preserved ejection fraction, with both obesity and metabolic health status independently contributing to cardiovascular event risk.

Impact: This large-scale analysis reveals unique cardiac phenotypes across metabolic categories, providing new insights for early cardiovascular risk assessment in metabolically diverse populations.

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