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Abstract #1056

Exploring the Link between Cerebral Small Vessel Disease and Alzheimer’s Disease with [11C]CS1P1, a Novel PET Tracer of Neuroinflammation

Inema Epere Orukari1, Yujie Wang1, Yasheng Chen2, Biwen Wang3,4, Karl Friedrichsen2, Matt Brier1,2, Ying Hwey Nai1, Lynne Jones1, Farzaneh Rahmani1, Jude-Patrick Okafor1, Jayashree Rajamanickam1, Shaney Flores1, Jin-Moo Lee2, Andria Ford2, Zhude Tu1, Tammie Benzinger1, and Hongyu An1
1Mallinckrodt Institute of Radiology, Washington University in St Louis, St Louis, MO, United States, 2Neurology, Washington University in St Louis, St Louis, MO, United States, 3Imaging Science, Washington University in St Louis, St Louis, MO, United States, 4Mallinckrodt Institute of Radiology, Washington University in St Louis, St. Louis, MO, United States

Synopsis

Keywords: Dementia, PET/MR

Motivation: This study investigates the use of [11C]CS1P1 PET imaging to assess neuroinflammation as an early biomarker of cerebral small vessel disease (cSVD) and Alzheimer’s Disease (AD).

Goal(s): The goal of this study is to assess whether [11C]CS1P1 uptake correlates with cSVD or AD burden.

Approach: The overall approach of this study is a prospective cross-sectional analysis correlating [11C]CS1P1 to white matter hyperintensity (WMH) burden and PiB Centiloid.

Results: Among 23 participants, results showed a correlation between WMH burden and [11C]CS1P1 PET uptake in both normal appearing white matter and gray matter, suggesting its utility in identifying high-risk areas for disease progression.

Impact: [11C]CS1P1 PET could be a biomarker of early AD and cSVD. This imaging approach could guide the timely application of disease-modifying therapies and possibly enhancing treatment outcomes.

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Keywords