Abstract #1057

DCE-MRI reveals elevated blood-brain barrier leakage of heterogeneous white matter in cerebral small vessel disease

Damon Verstappen^1,2, Joost J.A. de Jong^1,2, Paulien H.M. Voorter^1,2, Maud van Dinther^3,4, Maxime Gidding¹, Robert J. van Oostenbrugge^2,3,4, Julie Staals^3,4, Jacobus F.A. Jansen^1,2,5, and Walter H. Backes^1,2,4

¹Department of Radiology & Nuclear Medicine, Maastricht University Medical Centre, Maastricht, Netherlands, ²Mental Health and Neuroscience Research Institute (MHeNs)), Maastricht University, Maastricht, Netherlands, ³Department of Neurology, Maastricht University Medical Centre, Maastricht, Netherlands, ⁴Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, Netherlands, ⁵Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands

Synopsis

Keywords: Dementia, Vessels, Small vessel disease

Motivation: Blood-brain barrier (BBB) function is impaired in cerebral small vessel disease (cSVD), but challenging to detect with MRI.

Goal(s): To improve our understanding of regional BBB leakage variations in patients with cSVD.

Approach: BBB leakage was assessed in cSVD patients and age-matched controls using dynamic contrast-enhanced MRI. Inside the normal appearing white matter (NAWM) 2 mm thick shells were dilated from manually delineated white matter hyperintensities (WMH).

Results: WMH exhibited more widespread leakage in cSVD; the shells surrounding WMH showed that NAWM leaks more strongly in patients than controls, while no differences were found for the whole NAWM.

Impact: A more regionally targeted analysis is required to determine the subtle BBB leakage in the NAWM of patients with cSVD and to assess differences with controls.

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