Abstract #1058

The role of venous hemodynamics in cerebral small vessel disease

Wen Shi^1,2, Dengrong Jiang², Jie Song^1,2, Yifan Gou^1,2, Zhiyi Hu^1,2, Kaisha Hazel², George Pottanat², Ebony Jones², Julia Suconic², Cuimei Xu², Vivek Yedavalli², Paul Rosenberg³, Rita Kalyani⁴, Abhay Moghekar⁵, Sevil Yasar⁴, Doris Lin², Marilyn Albert⁵, and Hanzhang Lu^1,2

¹Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁵Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: Dementia, Vascular, Small vessel disease

Motivation: Post-mortem studies suggested that vascular cognitive impairment and dementia (VCID) are more strongly related to small vein abnormalities than to arteriolosclerosis. However, few studies have investigated the relationship between venous dysfunction and VCID in vivo.

Goal(s): To study the role of venous hemodynamics in cerebral small vessel disease (CSVD).

Approach: VICTR MRI was applied to patients with CSVD-related VCID to measure venous transit time (VTT) and venous cerebral blood volume (vCBV). Associations with imaging and clinical features were studied.

Results: Patients with longer VTT and larger vCBV were associated with more extensive white matter hyperintensities and greater vascular risks, particularly hypertension and diabetes.

Impact: Venous hemodynamics such as transit time and blood volume are associated with white matter hyperintensity and vascular risks. These measures may be useful as imaging markers to characterize venous abnormalities in cerebral small vessel disease.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.