Meeting Banner
Abstract #1060

Mapping Subjective Cognitive Decline to a Common Brain Network and Linking to Gene Expression Profiles

Huan Lan1, Wenxiong Liu1, Xueling Suo1, and Qiyong Gong1,2
1Department of Radiology and Huaxi MR Research Center (HMRRC), West China Hospital, Sichuan University, Chengdu, China, 2Department of Radiology, West China Xiamen Hospital of Sichuan University, Xiamen, China

Synopsis

Keywords: Dementia, biomarkers, subjective cognitive decline, brain network, neuroimaging, functional connectivity

Motivation: Whether the inconsistent findings of neuroimaging studies of subjective cognitive decline (SCD) could localize to a common brain network.

Goal(s): Our goal was to determine the convergent brain substrates of SCD and the associated microbiological profiles.

Approach: We used ‘coordinate network mapping’, utilizing a normative connectome (n = 1,000) of resting-state fMRI data to identify regions commonly connected to findings across all included studies. We decoded this convergent network through microscale transcriptomic and chemo-architectures.

Results: The heterogeneous findings localized to DMN and SMN, and colocalized with brain-wide gene expression involved in cellular signaling-related biological processes, and aligned with certain neurotransmitter systems.

Impact: Heterogeneous neuroimaging findings of SCD converge on common brain networks, which is linked to specific biological processes and neurotransmitters. This comprehensive understanding of the neural substrates underlying SCD may inform more targeted strategies to prevent dementia.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords