Abstract #1064

Brain connectome gradient dysfunction in patients with ESRD and its association with clinical phenotype and cognitive deficits

Peng Li^1,2, Li Ren³, Yanping Yang³, Xinyi Zhu⁴, Huijie Yuan⁴, Zhaoyao Luo⁴, Junya Mu⁴, Wen Wang¹, and Ming Zhang⁴

¹Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province, The Second Affiliated Hospital of Air Force Medical University, Xi'an, China, ²Department of Medical Imaging, Nuclear Industry 215 Hospital of Shaanxi Province, Xianyang, China, ³Department of Nephrology, Nuclear Industry 215 Hospital of Shaanxi Province, Xianyang, China, ⁴Department of Medical Imaging, First Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China

Synopsis

Keywords: Other Neurodegeneration, fMRI (resting state), End-stage renal disease; Gradient; Sensorimotor; Cognitive impairment

Motivation: Whether the cortical gradient structure is disrupted in patients with ESRD and how this disruption provides valuable information for potential clinical interventions remain unknown.

Goal(s): Explore brain connectome gradient dysfunction in patients with ESRD and its association with clinical phenotype and cognitive deficits.

Approach: Resting-state fMRI was used to investigate ESRD-related hierarchical alterations. The Neurosynth platform and machine learning classification models were used to assess the meta-analytic cognitive functions and discriminative power.

Results: The connectome gradient dysfunction mainly located in DMN and SMN, which were correlated with serum creatinine, depression status, and cognitive terms in patients with ESRD.

Impact: This is the first study to reveal the brain connectome hierarchical dysfunction in ESRD patients and its association with clinical phenotype and cognitive deficits, which might be used as an potential neuroimaging marker for clinical symptoms in ESRD patients.

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