Abstract #1065

Comparison of Postoperative Recurrence Prediction Capability among CEST, DWI, PET/CT and Combined Indexes in Stage I Non-Small Cell Lung Cancer

Yoshiyuki Ozawa¹, Kaori Yamamoto², Masanori Ozaki², Masato Ikedo², Masao Yui², Hiroyuki Nagata³, Takahiro Ueda¹, Masahiko Nomura¹, Takeshi Yoshikawa¹, Daisuke Takenaka¹, and Yoshiharu Ohno^1,3

¹Diagnostic Radiology, Fujita Health University School of Medicine, Toyoake, Japan, ²Canon Medical Systems Corporation, Otawara, Japan, ³Joint Research Laboratory of Advanced Medical Imaging, Fujita Health University School of Medicine, Toyoake, Japan

Synopsis

Keywords: Cancer, Cancer, CEST

Motivation: CEST has a potential to play a complementary role for prediction of postoperative recurrence and improve the prediction capability as compared with DWI, CEST and FDG-PET/CT in NSCLC patients.

Goal(s): The goal was to compare the quantitative prediction capability for postoperative recurrence of FDG-PET/CT and MRI-based molecular information from CEST and DWI in stage I NSCLC patients.

Approach: This clinical study examined CEST imaging, DWI and FDG-PET/CT, and all indexes and combined predictors were compared prediction capabilities in NSCLC.

Results: Specificities and accuracies of MTR_asym, ADC and combined predictors were significantly higher than those of SUV_max (p<0.05).

Impact: MRI-based molecular information has better potential for prediction of postoperative recurrence than FDG-PET/CT in stage I NSCLC patients. Moreover, combined CEST and DWI information can improve prediction capability of CEST imaging in this setting.

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