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Abstract #1092

Quantifying Free Water Content with the Look-Locker Method in MRI

Junyu Guo1, Chunwei Ying2, Basak Dogan1, and Ivan Pedrosa1
1UT Southwestern Medical Center, Dallas, TX, United States, 2Siemens Medical Solutions USA, Dallas, TX, United States

Synopsis

Keywords: Quantitative Imaging, Quantitative Imaging, Proton density map

Motivation: Accurate free water fraction quantification is a promising approach for advancing diagnostics and treatment monitoring across diseases, with a need for improved methods to enhance tumor characterization.

Goal(s): To develop and validate a method for quantifying water using the Look-Locker technique (qWaLL), aimed at accurately measuring free water fraction with the Look-Locker sequence.

Approach: We employ a qWaLL method to correct transmitting and receiving coil inhomogeneities, enabling the robust generation of highly accurate water fraction maps.

Results: Our qWaLL method yielded water fraction maps with improved accuracy, demonstrating significantly reduced deviations from reference values, particularly enhancing diagnostic potential in clinical applications.

Impact: This study demonstrates a highly accurate, optimized method for quantifying water fraction using the Look-Locker sequence (qWaLL), improving artifact removal and signal homogeneity. It offers significant potential for enhancing diagnostic precision in tumor tissue characterization and clinical applications.

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Keywords