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Abstract #1096

Highly-efficient simultaneous 3D radial joint T1-T2-FF mapping for isotropic resolution liver imaging at 0.55T

Nicolás Garrido1,2,3, Carlos Castillo-Passi1,2,3, Karl Kunze4, Claudia Prieto1,3,5, and René Botnar1,2,3,5
1iHEALTH Millenium Institute, Santiago, Chile, 2Institute for Biological and Medical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile, 3School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 4MR Research Collaborations, Siemens Healthcare Limited, Camberley, United Kingdom, 5School of Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile

Synopsis

Keywords: Quantitative Imaging, Low-Field MRI

Motivation: Low-field MRI has potential to provide affordable diagnosis of non-alcoholic fatty liver disease. T1-T1-FF are important biomarkers as they provide information on fat, inflammation and fibrosis; yet clinical scans are lengthy and affected by respiratory motion.

Goal(s): To investigate the feasibility of an efficient 3D-radial T1-T2-FF sequence for evaluating liver integrity at 0.55T.

Approach: A free-running, 3D-radial, golden-angle sequence with spoiled gradient-echo readout was implemented, achieving 2.5mm isotropic resolution for joint T1-T2-FF mapping in 4min.

Results: The sequence was tested on a T1-T2-FF phantom, showing good agreement with references. Promising results were obtained in healthy subjects, obtaining T1-T2-FF whole liver maps in 4min.

Impact: Highly-efficient 3D radial joint T1-T2 and FF mapping of the liver using low-field MRI could provide a more affordable, accessible, and comprehensive approach for liver disease assessment.

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