Abstract #1126

Direct and Quantitative Assessment of Brain Bioenergetics in Young Adults with Depression

Xiao-Hong Zhu¹, Hannes M Wiesner¹, Bonnie Klimes-Dougan², Wei Chen¹, and Kathryn R Cullen³

¹Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, United States, ²Psychology Department, College of Liberal Arts, University of Minnesota, Minneapolis, MN, United States, ³Child and Adolescent Psychiatry Division, Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, United States

Synopsis

Keywords: Psychiatric Disorders, Brain

Motivation: Feeling low on energy is a core feature of depression and can severely impact patients' daily functioning. Direct assessment of neuro-energetic state is essential for better understanding and managing depression.

Goal(s): To perform a neuro-energetic pilot study in young adults with depression.

Approach: Clinical depression assessment and 7T in vivo ³¹P MRS-MT imaging measurement were performed on young adults with and without depression. Key cerebral bioenergetic parameters were quantified and analyzed together with the depression and fatigue severity scores.

Results: Statistically significant higher brain ATP production rate was detected in depression patients at rest, which showed positive correlation with their fatigue severity.

Impact: We demonstrate that the ³¹P MRS-MT imaging technique is able to quantitatively evaluate key bioenergetic parameters in the human brain, revealing new insights into the cerebral energetic alterations underlying fatigue in young adults with depression.

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