Abstract #1127

Quantitative Susceptibility Mapping of Subcortical Regions in Major Depression Using Susceptibility Separation Technique

Shuhei Shibukawa^1,2,3, Hirohito Kan⁴, Shinichiro Nakajima⁵, Yoshihiro Noda⁶, and Shinsuke Koike¹

¹Center for Evolutionary Cognitive Sciences, Graduate School of Art and Sciences, The University of Tokyo, Tokyo, Japan, ²Department of Radiological Technology, Faculty of Health Science, Juntendo University, Tokyo, Japan, ³Department of Radiology, Tokyo Medical University, Tokyo, Japan, ⁴Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Aichi, Japan, ⁵Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan, ⁶Keio University School of Medicine, Department of Neuropsychiatry, Japan

Synopsis

Keywords: Psychiatric Disorders, Psychiatric Disorders, Quantitative Susceptibility Mapping

Motivation: Major Depressive Disorder (MDD) is associated with abnormalities in subcortical structures involved in emotion regulation and reward processing, though the specific causes remain unclear.

Goal(s): This study aims to evaluate susceptibility changes in subcortical regions to differentiate MDD patients from healthy controls.

Approach: QSM-ARCS was used to separate paramagnetic (iron) and diamagnetic (myelin) sources in susceptibility maps, allowing detailed analysis of subcortical regions.

Results: Significant group differences were observed in positive and negative susceptibility associated with iron and myelin changes in the MDD group, highlighting abnormalities in subcortical regions.

Impact: QSM-ARCS revealed iron and myelin changes in the subcortical structures of MDD, deepening understanding of MDD pathophysiology and highlighting its potential to advance future diagnostic and therapeutic strategies.

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