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Abstract #1141

3D free-breathing water-specific abdominal T1 and T2 mapping using Cartesian sampling with spiral profile ordering (CASPR)

Jonathan Stelter1, Kilian Weiss2, Jakob Meineke3, Weitong Zhang4, Bernhard Kainz4,5, Rickmer F. Braren1, and Dimitrios C. Karampinos1
1School of Medicine and Health, Technical University of Munich, Munich, Germany, 2Philips GmbH Market DACH, Hamburg, Germany, 3Philips Innovative Technologies, Hamburg, Germany, 4Department of Computing, Imperial College London, London, United Kingdom, 5Department Artificial Intelligence in Biomedical Engineering, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

Synopsis

Keywords: Relaxometry, Quantitative Imaging, Acquisition & Reconstruction

Motivation: Look-Locker-based methods have shown great efficiency for abdominal T1 mapping, but the combination with preparation-based 3D T2 mapping is challenging due to increasing scan times.

Goal(s): To develop an efficient, motion-robust and confounder-corrected method for simultaneous abdominal water-specific T1 (wT1) and T2 (wT2) mapping.

Approach: A T2-prepared inversion Look-Locker scheme was combined with a large-FOV Cartesian acquisition with spiral profile ordering. wT1 and wT2 maps were estimated using a soft-gated subspace reconstruction, dual-echo water-fat separation and B0-specific dictionary matching.

Results: Phantom and in vivo experiments show good quantification at 3T and demonstrate the reproducibility and flexibility of the proposed method at different resolutions.

Impact: Simultaneous water T1 and T2 mapping is achieved in a scan time of 5min at isotropic resolution of 3mm using a T2-prepared Look-Locker scheme with large-FOV CASPR sampling. This technique may be valuable in assessing diffuse and focal abdominal diseases.

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Keywords