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Abstract #1173

Functional Sodium MRI Helps to Measure Corticomedullary Sodium Content in Superior and Inferior Function of Transplant Kidney

Gen Chen1, Zhouyan Liao1, Siyuan Ma1, Pan Luo1, Xiaoxiao Zhang2, Qiuxia Wang1, Hao Tang1, and Zhen Li1
1Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 2MSC Clinical & Technical Solutions, Philips Healthcare, Beijing, China

Synopsis

Keywords: Kidney, Kidney, Sodium MRI,cortico-medullary gradient

Motivation: This study is motivated by tools to explore transplanted kidney tubular function is still not well developed.

Goal(s): Assessing the performance of sodium cortico-medullary gradient (CMG) in evaluating the ability of the transplanted kidney to concentrate urine, transplant kidney function and biopsy scoring.

Approach: CMG was estimated by measuring the medulla-to-cortex signal ratio from sodium MRI. Pearson or spearman correlation was performed between CMG and urine specific gravity, eGFR, and the biopsy scoring.

Results: The medulla-to-cortex ratio was significantly correlated with mean urine specific gravity and eGFR, and also showed significant correlation with t - IFTA of the Banff score.

Impact: Sodium MRI accurately depicted CMG in transplanted kidney that correlated with ability of concentrate urine. CMG was related to eGFR and t-IFTA. The findings will contribute to develop non-invasive imaging method to evaluation tubular function and disease of transplanted kidney.

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