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Abstract #1218

Utilizing Blood Clots as Intrinsic Contrast Agents in Postmortem Vascular MRI at 7T

Chenyang Li1,2, Huize Pang1,2, Zhe Sun1,2, Miaoqi Zhang1,2, Li Jiang1,2, Annie Li1,2, Dominique Leitner3, Thomas Wisniewski3, Arline Faustin3, Orrin Devinsky4, Mary Bruno1,2, Youssef Zaim Wadghiri1,2, Jiangyang Zhang1,2, and Yulin Ge1,2
1Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, 2Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, 3Center for Cognitive Neurology, Department of Neurology, NYU Grossman School of Medicine, New York, NY, United States, 4Comprehensive Epilepsy Center, Department of Neurology, NYU Grossman School of Medicine, New York, NY, United States

Synopsis

Keywords: Blood Vessels, Ex-Vivo Applications, Gradient echo; Postmortem MRI; Vascular Imaging

Motivation: While in vivo vascular imaging is well-characterized, the imaging features of vascular morphology and properties in postmortem brain samples remain poorly understood.

Goal(s): To characterize postmortem brain vascular MRI features compared to in vivo imaging.

Approach: We hypothesized to use blood clot as intrinsic contrast and use high-resolution T2*-weighted gradient echo imaging on both clinical and preclinical 7T scanners, with histopathological staining to validate blood clot formation.

Results: Postmortem blood vessels showed contrast patterns similar to in vivo Ferumoxytol-enhanced SWI, particularly in smaller vessels, suggesting distinct changes in blood properties after death.

Impact: The imaging characteristics of postmortem blood clots on T2*-W MRI enable detailed mapping of brain small vessel architecture, with contrast similar to in vivo Ferumoxytol-enhanced imaging, offering a novel method to study postmortem vasculature and imaging correlates to vascular pathology.

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Keywords