Abstract #1225

Aneurysm Wall Permeability Measured by DCE-MRI as a Predictor of Growth in Non-Saccular Intracranial Aneurysms at Follow-up

Yan Li¹, Ziming Xu¹, Linggen Dong², Yajie Wang¹, Peng Liu², Ming Lv², and Huijun Chen¹

¹Center for Biomedical Imaging Research, Tsinghua University, Beijing, China, ²Department of Neurosurgery, Beijing Tiantan Hospital, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China

Synopsis

Keywords: Blood Vessels, DSC & DCE Perfusion

Motivation: Predicting the rupture risk of non-saccular intracranial aneurysms is critical, as growing aneurysms have higher rupture risk than stable ones.

Goal(s): This study aimed to predict the growth of non-saccular intracranial aneurysms using wall permeability (K^trans) from DCE-MRI.

Approach: Patients were classified into growth and non-growth groups based on aneurysm size changes during a median follow-up period of 7.5 months. We investigated the potential of demographic and imaging characteristics in predicting aneurysm growth.

Results: K^trans was the most effective biomarker in identifying aneurysm growth with the highest AUC of 0.778, and higher K^trans regions were correlated with the direction of aneurysm growth.

Impact: This study demonstrates that baseline K^trans, derived from DCE-MRI, is an effective predictor of non-saccular intracranial aneurysm growth. It offers a valuable tool for predicting aneurysm growth and enhancing rupture risk prediction in clinical practice.

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