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Abstract #1230

Application of DTI and Resting State fMRI in Clinical Trial of Neural Stem Cells (NR1) Intracerebral Transplantation for Chronic Ischemic Stroke

Bin Jiang1, Donghoon Kim1, Tie Liang2, Greg Zaharchuk1, Michael Zeineh2, and Gary K Steinberg2
1Stanford University, Stanford, CA, United States, 2Stanford University, stanford, CA, United States

Synopsis

Keywords: Stroke, Stroke, Cell therapy, neurorestoration, MRI, DTI, fMRI

Motivation: Stem cell interventions demonstrated safety and efficacy in previous clinical trials; however, advanced neuroimaging methodology was rarely used to monitor the effect of functional recovery and outcome prediction.

Goal(s): Investigate changes in neuroimaging measures following a Phase 1/2a unblinded, single-arm stem cell–based clinical trial in patients with chronic ischemic stroke.

Approach: DTI and rs-fMRI processing pipelines were employed for data analysis to secure the reproducibility of the results.

Results: Ipsi-lesional FICVF in the splenium of the corpus callosum significantly correlated with FMscore at 30days with increased connectivity in the contra-lesional sensorimotor area at 6months and 1year, suggesting recovery/adaptive processes in response to treatment.

Impact: Monitoring neuroimaging changes may facilitate patient selection and predict both short- and long-term responses to cell therapy. Further data collection and molecular analysis are necessary to deepen our understanding of brain changes following stem cell therapy.

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