Keywords: Stroke, Stroke, Cell therapy, neurorestoration, MRI, DTI, fMRI
Motivation: Stem cell interventions demonstrated safety and efficacy in previous clinical trials; however, advanced neuroimaging methodology was rarely used to monitor the effect of functional recovery and outcome prediction.
Goal(s): Investigate changes in neuroimaging measures following a Phase 1/2a unblinded, single-arm stem cell–based clinical trial in patients with chronic ischemic stroke.
Approach: DTI and rs-fMRI processing pipelines were employed for data analysis to secure the reproducibility of the results.
Results: Ipsi-lesional FICVF in the splenium of the corpus callosum significantly correlated with FMscore at 30days with increased connectivity in the contra-lesional sensorimotor area at 6months and 1year, suggesting recovery/adaptive processes in response to treatment.
Impact: Monitoring neuroimaging changes may facilitate patient selection and predict both short- and long-term responses to cell therapy. Further data collection and molecular analysis are necessary to deepen our understanding of brain changes following stem cell therapy.
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